HMG: axis restart vs fertility framing
HMG (performance) vs HMG (peptides)
The table compares the compounds’ key data from their entry pages. Open each compound’s full entry for details. Educational content, not medical advice.
| HMG (Menopur / Pergonal) | HMG (Fertility) | |
|---|---|---|
| What it is | Human Menopausal Gonadotropin – urinary-extracted FSH + LH 75/75 IU mixture. In AAS-PCT: full HPG axis restart (Sertoli FSH support too, not just Leydig LH like HCG). Pergonal withdrawn 2005, Menopur modern alternative. Cross-frame: future peptide library will add `hmg-peptid`. | Human Menopausal Gonadotropin – 1:1 FSH+LH glycoprotein. Full spermatogenesis induction (dual Leydig + Sertoli axis), IVF superovulation. Clinical Rx for infertility indications (male HypoH + female IVF ovulation induction), NOT doping. Cross-frame: AAS-PCT context covered by the `hmg-perf` entry. |
| Mechanism of action | Urinary-extracted FSH (75 IU) + LH (75 IU) mixture – Sertoli-FSHR + Leydig-LHCGR receptor double-stimulus | 1:1 FSH+LH glycoprotein mixture – Sertoli-FSHR + Leydig-LHCGR receptor double-stimulus, full HPG axis induction |
| Half-life | FSH ~24-36 h / LH ~20 h (mixed component decay) | FSH component ~12-20 h / LH component ~8-12 h |
| Legal status | EMA Rx Menopur (Ferring 2002), USA FDA Rx Menopur (2005), WADA S2 (banned) | FDA + EMA Rx Menopur (Ferring), WADA S2 (banned in+out-of-competition) |
| Full entry | Open → | Open → |
What it is
HMG (Menopur / Pergonal)Human Menopausal Gonadotropin – urinary-extracted FSH + LH 75/75 IU mixture. In AAS-PCT: full HPG axis restart (Sertoli FSH support too, not just Leydig LH like HCG). Pergonal withdrawn 2005, Menopur modern alternative. Cross-frame: future peptide library will add `hmg-peptid`.
HMG (Fertility)Human Menopausal Gonadotropin – 1:1 FSH+LH glycoprotein. Full spermatogenesis induction (dual Leydig + Sertoli axis), IVF superovulation. Clinical Rx for infertility indications (male HypoH + female IVF ovulation induction), NOT doping. Cross-frame: AAS-PCT context covered by the `hmg-perf` entry.
Mechanism of action
HMG (Menopur / Pergonal)Urinary-extracted FSH (75 IU) + LH (75 IU) mixture – Sertoli-FSHR + Leydig-LHCGR receptor double-stimulus
HMG (Fertility)1:1 FSH+LH glycoprotein mixture – Sertoli-FSHR + Leydig-LHCGR receptor double-stimulus, full HPG axis induction
Half-life
HMG (Menopur / Pergonal)FSH ~24-36 h / LH ~20 h (mixed component decay)
HMG (Fertility)FSH component ~12-20 h / LH component ~8-12 h
Legal status
HMG (Menopur / Pergonal)EMA Rx Menopur (Ferring 2002), USA FDA Rx Menopur (2005), WADA S2 (banned)
HMG (Fertility)FDA + EMA Rx Menopur (Ferring), WADA S2 (banned in+out-of-competition)