Melanocortin receptor agonistsα-MSH / melanocortin agonistA peptide that activates melanocortin receptors (an α-melanocyte-stimulating-hormone analogue), modulating pigmentation and other central pathways.
Melanotan-2 vs PT-141
The table compares the compounds’ key data from their entry pages. Open each compound’s full entry for details. Educational content, not medical advice.
 Melanotan-2 |  PT-141 | |
|---|---|---|
| What it is | Synthetic α-MSH analog: pigmentation and libido modulation | Melanocortin receptor agonist: FDA approved (bremelanotide) |
| Type | Cyclic heptapeptide (MC1-5R agonist) | Melanocortin receptor agonist (MC3R/MC4R) |
| Structure | Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂ | Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH |
| Molecular weight | ~1024 Da | ~1025 Da |
| Target area | Skin pigmentation, libido | Sexual desire (HSDD) |
| Storage | 2–8°C (reconstituted) | 2–8°C (reconstituted) |
| Stability | 25–30 days (reconstituted) | 25–30 days (reconstituted) |
| Full entry | Open → | Open → |
What it is
Melanotan-2Synthetic α-MSH analog: pigmentation and libido modulation
PT-141Melanocortin receptor agonist: FDA approved (bremelanotide)
Type
Melanotan-2Cyclic heptapeptide (MC1-5R agonist)
PT-141Melanocortin receptor agonist (MC3R/MC4R)
Structure
Melanotan-2Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂
PT-141Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH
Molecular weight
Melanotan-2~1024 Da
PT-141~1025 Da
Target area
Melanotan-2Skin pigmentation, libido
PT-141Sexual desire (HSDD)
Storage
Melanotan-22–8°C (reconstituted)
PT-1412–8°C (reconstituted)
Stability
Melanotan-225–30 days (reconstituted)
PT-14125–30 days (reconstituted)
Full entry