GABA-B agonists (Phenibut family)GABA-B agonistA compound that activates the GABA-B inhibitory neurotransmitter receptor.
Phenibut vs F-Phenibut
The table compares the compounds’ key data from their entry pages. Open each compound’s full entry for details. Educational content, not medical advice.
| PPhenibut | FF-Phenibut | |
|---|---|---|
| What it is | β-phenyl-GABA, GABA-B agonist, Russian prescription anxiolytic. | Fluorinated Phenibut, more potent, more lipophilic GABA-B agonist variant. |
| MechanismMechanism of actionThe molecular pathway by which a compound acts in the body (e.g. which receptor or enzyme it binds). | GABA-B agonist + Ca²⁺-α2δ | GABA-B agonist (Phenibut-like) |
| Half-lifeHalf-lifeThe time for the compound’s plasma concentration to fall by half; indicates how fast it clears and how often it is dosed. | ~5 h | No validated human data |
| Legal statusLegal / WADA statusThe compound’s regulatory status (e.g. prescription) and its place on the WADA prohibited-in-sport list. | Russia Rx / UK Class C (2024) | Not approved anywhere |
| Full entry | Open → | Open → |
What it is
Phenibutβ-phenyl-GABA, GABA-B agonist, Russian prescription anxiolytic.
F-PhenibutFluorinated Phenibut, more potent, more lipophilic GABA-B agonist variant.
MechanismMechanism of actionThe molecular pathway by which a compound acts in the body (e.g. which receptor or enzyme it binds).
PhenibutGABA-B agonist + Ca²⁺-α2δ
F-PhenibutGABA-B agonist (Phenibut-like)
Half-lifeHalf-lifeThe time for the compound’s plasma concentration to fall by half; indicates how fast it clears and how often it is dosed.
Phenibut~5 h
F-PhenibutNo validated human data
Legal statusLegal / WADA statusThe compound’s regulatory status (e.g. prescription) and its place on the WADA prohibited-in-sport list.
PhenibutRussia Rx / UK Class C (2024)
F-PhenibutNot approved anywhere
Full entry