Bromantane
Russian actoprotector, dopaminergic + serotonergic modulator + immunomodulator. Anti-fatigue, anxiolytic.
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Pharmacology
Contents
WHAT IS BROMANTANE?
Detailed overview
Bromantane (Ladasten, ADK-709) is an adamantane-aminobenzol derivative developed in Russia originally as a military actoprotector (physical + mental performance under stress, heat tolerance). Unusual mechanism: upregulates tyrosine hydroxylase + DOPA decarboxylase expression (dopamine synthesis), modulates serotonin and GABA, and acts as a mild immunomodulator (cytokine synthesis regulation). Rx in Russia for chronic fatigue, neurasthenia, asthenic disorders. WADA-listed (S0 non-approved substances).
Mechanism
Dopaminergic + serotonergic actoprotector
Half-life
10-14 hours
Onset
60-90 min
Legal status
Russia Rx, EU/USA research
Receptor profile
- Dopamine synthesis (TH, AADC)Moderate
- Stress response (actoprotector)Moderate
- SerotoninWeak
- D2R signaling on indirect-pathway MSNs (iMSNs)Strong
- HDAC1Moderate
Safety
Side effects, stop signs, contraindications
Side effects · 7
- Sleep disturbance, insomnia (especially with evening dosing, due to dopaminergic activation)
- Irritability, restlessness
- Mild dry mouth
- Headache
- Appetite loss and increased thirst at high doses (>200 mg/day)
- Tolerance with prolonged use, requiring cycling off
- Individual variability: mild sedation rather than stimulation in some users
Contraindications · 6
- Avoid with MAO inhibitors (risk of serotonin syndrome and hypertensive crisis)
- Pregnancy and breastfeeding (no human safety data)
- Bipolar disorder (dopaminergic activation may trigger a manic episode)
- Active psychotic disorder (dopaminergic overstimulation may worsen symptoms)
- Severe cardiovascular or hepatic disease
- Prohibited for competitive athletes (WADA S0, non-approved substances)
Related Nootropics
Same therapeutic category
Studies
Related research and clinical findings
[The mechanisms of the neurotropic action of bromantan].
Morozov IS, Pukhova GS, Avdulov NA, Sergeeva SA, Lukicheva TA, Kashtanov SI
[Role of the brain dopaminergic and serotoninergic systems in psychopharmacological effects of ladasten and sydnocarb].
Zimin IA, Abaimov DA, Budygin EA, Zolotarev IuA, Kovalev GI
FAQ
FAQ
Bromantane is a Russian-developed compound originally created for military use, to fight fatigue and sustain performance under stress or cold. According to the sources it works as an anti-anxiety agent without causing drowsiness, and Russian studies suggest it can improve endurance and resilience to physical stress. Most of the evidence comes from Russian clinical and sports research, so independent human data outside Russia is scarce.
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Structure & chemistry
The information here is strictly for educational and scientific purposes. It does not replace medical advice or clinical consultation, and it does not encourage illegal substance or pharmaceutical use. Data is sourced. When in doubt, consult your doctor.