Compound 7P
Sulfonamidoacetamide axon-regeneration inducer, prostanoid modulator, preclinical data only.
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Pharmacology
Contents
WHAT IS COMPOUND 7P?
Detailed overview
Compound 7P is a sulfonamidoacetamide experimental compound identified and optimized as an inducer of axon regeneration in a 2016 medicinal-chemistry study (PMID 27007292). It acts on prostanoid signaling, blocking the thromboxane A2 receptor and its synthesis while promoting prostacyclin (PGI2) production, thereby tipping the balance toward a growth-permissive, regenerative neuronal state via the mTOR and STAT3 pathways. In cultured hippocampal, cortical and retinal neurons it stimulated neurite outgrowth, and in a rat optic-nerve injury model it induced growth of GAP-43-positive axons. There is essentially no human clinical data: the compound has never been approved for human use and exists only as a laboratory research chemical.
Mechanism
Thromboxane block + prostacyclin shift (mTOR/STAT3)
Evidence
Preclinical only (cell + animal)
Legal status
Unapproved research chemical
Receptor profile
- Neurite outgrowth / axon regeneration (mTOR, STAT3)Moderate
- Thromboxane A2 receptor / synthase (inhibition)Moderate
- Prostacyclin (PGI2) synthase selectivityWeak
Safety
Side effects, stop signs, contraindications
Side effects · 4
- No human safety data: an early-stage research compound studied only in cell and animal models
- Theoretical platelet and blood-vessel effects from shifting the prostanoid (thromboxane/prostacyclin) balance, uncharacterized in humans
- The prostacyclin shift may theoretically cause vasodilation, lower blood pressure or increased bleeding tendency
- Unknown long-term safety and an entirely missing human toxicity profile
Contraindications · 4
- Pregnancy and breastfeeding: safety not established, avoid
- People on anticoagulants or antiplatelet drugs: prostanoid modulation may theoretically increase bleeding risk
- Bleeding disorder or upcoming surgery: avoid due to theoretical platelet effects
- Not an approved drug and not a dietary supplement; experimental research chemical, not recommended without clinical supervision
Related Nootropics
Same therapeutic category
Studies
Related research and clinical findings
Discovery, Optimization, and Biological Evaluation of Sulfonamidoacetamides as an Inducer of Axon Regeneration
Ku JM, Taher M, Chin KY, et al.
Thromboxane A2 stimulates neurite outgrowth in cerebral cortical neurons via mitogen activated protein kinase signaling
Sumimoto S, et al.
FAQ
FAQ
Sulfonamidoacetamide axon-regeneration inducer, prostanoid modulator, preclinical data only.
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Structure & chemistry
The information here is strictly for educational and scientific purposes. It does not replace medical advice or clinical consultation, and it does not encourage illegal substance or pharmaceutical use. Data is sourced. When in doubt, consult your doctor.