Lemairamin
Zanthoxylum-derived α7 nicotinic agonist; anti-inflammatory neuroprotectant, preclinical only.
Pharmacology
Contents
WHAT IS LEMAIRAMIN?
Detailed overview
Lemairamin (also called Wgx-50 or gx-50) is a protoalkaloid amide isolated from the pericarp of Sichuan pepper (Zanthoxylum species), identified as an agonist of the alpha-7 nicotinic acetylcholine receptor. By activating the alpha-7 nAChR it engages both cognitive signaling and the cholinergic anti-inflammatory pathway: it suppresses microglial inflammatory activation, lowers pro-inflammatory cytokines, and acts as a neuroprotectant through the JAK2/STAT3 and PI3K/AKT pathways. In preclinical models it reduced pain sensitivity, attenuated beta-amyloid accumulation and improved cognitive readouts in Alzheimer's models. There are essentially no human clinical trials: human pharmacokinetics and safety are uncharacterized, so it exists only as an experimental natural-product compound.
Mechanism
Alpha-7 nAChR agonist + anti-inflammatory
Evidence
Preclinical only (no human data)
Origin
Zanthoxylum (Sichuan pepper) protoalkaloid
Receptor profile
- Alpha-7 nicotinic acetylcholine receptorsStrong
- JAK2/STAT3 and PI3K/AKT anti-inflammatory signalingModerate
- Beta-amyloid aggregation / channels (inhibition)Moderate
- Microglia-mediated neuroinflammation (suppression)Moderate
Safety
Side effects, stop signs, contraindications
Side effects · 4
- No human safety data: evidence comes only from preclinical (rodent, zebrafish and in silico) studies
- Theoretical cholinergic overstimulation (nausea, sweating, increased gut motility) at high doses
- Unknown long-term safety and uncharacterized toxicity profile in humans
- Possible gastrointestinal irritation or allergic reaction typical of Zanthoxylum extracts
Contraindications · 3
- Pregnancy and breastfeeding: safety not established, avoid
- Known allergy to Zanthoxylum (Sichuan pepper) or related spice plants
- Not an approved medicine; experimental compound, not recommended without clinical supervision
Related Nootropics
Same therapeutic category
Studies
Related research and clinical findings
Lemairamin, isolated from the Zanthoxylum plants, alleviates pain hypersensitivity via spinal alpha7 nicotinic acetylcholine receptors
Liu M, et al.
Gx-50 Inhibits Neuroinflammation via alpha7 nAChR Activation of the JAK2/STAT3 and PI3K/AKT Pathways
Battdorj B, et al.
Inhibition of beta-Amyloid Channels with a Drug Candidate wgx-50 Revealed by Molecular Dynamics Simulations
Fan J, et al.
Lemairamin (Wgx-50) Attenuates DSS-Induced Intestinal Inflammation in Zebrafish
Wang Y, et al.
IL-10/beta-Endorphin-Mediated Neuroimmune Modulation on Microglia during Antinociception
Tsai RY, et al.
FAQ
FAQ
Zanthoxylum-derived α7 nicotinic agonist; anti-inflammatory neuroprotectant, preclinical only.
Telegram
Have a question about Lemairamin?
Reach out to us on Telegram for a personalized stack. We'll be happy to help.
Personalized consultation
Want a detailed conversation tailored to your data?
Fill out the prep intake form (your goals, training and health data), and the advisor prepares from it to give genuinely personalized guidance.
Fill out the form~5–7 min · prep questionnaire · confidential · GDPR-compliant
Structure & chemistry
The information here is strictly for educational and scientific purposes. It does not replace medical advice or clinical consultation, and it does not encourage illegal substance or pharmaceutical use. Data is sourced. When in doubt, consult your doctor.