There is no human safety data. It is sold as a research chemical with unverified identity and purity, so its safety is not established. The available literature covers analytical identification only, not clinical safety.

How does it differ from modafinil and flmodafinil?

Modafiendz is the N-methylated derivative of flmodafinil, the bis-(4-fluoro) analog of modafinil. The two fluorine atoms plus the N-methyl group distinguish it from modafinil; the real pharmacological differences have not been tested in humans.

Is there evidence for its efficacy?

Essentially none. It has only been identified in analytical and forensic studies (in supplements and as a GC degradation subject), with no human or animal efficacy testing. Its evidence level is therefore reference-only.

EmergingResearch compoundReference only

Modafiendz

Name: Modafiendz
Creator: MolekulaX

N-methyl analog of bis-(4-fluoro) modafinil, a eugeroic sold as a research chemical. Essentially no human data exists, only analytical and forensic characterization.

NootropicPerformance BoosterWellnessEugeroicDopaminergicFocusStimulantDopamineNorepinephrineGlutamateAnti-fatigue

Pharmacology

ClassEugeroic · Dopaminergic · Focus · Stimulant

Primary targetDopamine transporter (DAT), weak presumed reuptake inhibitor

Targets3 receptor targets

Half-lifeN/A (not characterized)

OnsetN/A (not characterized)

EvidenceReference only

Affected systemsDopamineNorepinephrineGlutamateAnti-fatigue

Contents

WHAT IS MODAFIENDZ?

Detailed overview

Modafiendz is a synthetic fluorinated analog of modafinil: chemically 2-[bis(4-fluorophenyl)methylsulfinyl]-N-methylacetamide, i.e. the N-methylated derivative of flmodafinil (bisfluoromodafinil). It has surfaced as a research chemical and as an unapproved ingredient spiked into products marketed as dietary supplements, and is not a licensed medicine anywhere. Its presumed mechanism mirrors modafinil, weak dopamine transporter (DAT) inhibition, but essentially no dedicated pharmacological research exists on it. The available literature deals purely with analytical and forensic identification, not with human or animal effects.

Mechanism

Presumed DAT inhibitor (unproven)

Half-life

Not characterized

Onset

Not characterized

Legal status

Research chemical, not a medicine anywhere

Evidence

Analytical/forensic data only

Receptor profile

Dopamine transporter (DAT)Moderate
Orexin / wake-promoting circuitsWeak
Mesencephalic dopamine neuronsModerate

Safety

Side effects, stop signs, contraindications

Side effects · 5

Headache or anxiety (common to eugeroics)
Insomnia if taken too late in the day
Possible elevated heart rate or blood pressure
Unknown long-term safety
Unverified identity and purity (research chemical)

Contraindications · 5

Cardiovascular disease: avoid due to possible blood pressure and heart rate increase
Pregnancy and breastfeeding: no safety data, avoid
Anxiety disorder or insomnia: the wakefulness-promoting effect may worsen them
Concurrent stimulant or MAOI use: additive or unknown risk
Competitive sport: as a modafinil analog likely prohibited (WADA S6 catch-all clause)

Related Nootropics

Same therapeutic category

Studies

Related research and clinical findings

J Diet Suppl. 2025;22(2):329-344.

Development and Validation of an Analytical Method to Identify and Quantitate Novel Modafinil Analogs in Products Marketed as Dietary Supplements

Bakota EL, Nandrea JM.

PMID: 39466147Open

Drug Test Anal. 2017;9(3):518-528.

Outsmarted by nootropics? An investigation into the thermal degradation of modafinil, modafinic acid, adrafinil, CRL-40,940 and CRL-40,941 in the GC injector

Dowling G, Kavanagh PV, Talbot B, et al.

PMID: 27928893Open

FAQ

N-methyl analog of bis-(4-fluoro) modafinil, a eugeroic sold as a research chemical. Essentially no human data exists, only analytical and forensic characterization.

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Structure & chemistry

TypeNootropic

FormulaC16H15F2NO2S

UpdatedJuly 9, 2026

MolekulaX Editorial Team·Source-verified · PubMed · FDA · EMA

Updated: July 9, 2026

The information here is strictly for educational and scientific purposes. It does not replace medical advice or clinical consultation, and it does not encourage illegal substance or pharmaceutical use. Data is sourced. When in doubt, consult your doctor.