Nooglutyl
Russian AMPA-PAM research compound, plasticity enhancer.
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Pharmacology
Contents
DETAILED OVERVIEW
What is Nooglutyl?
Nooglutyl (NSG, ONK-10, N-5-oxynicotinoyl-L-glutamic acid) is an experimental compound developed at the Pharmacology Institute of the Russian Academy of Sciences (Moscow), structurally related to Picamilon. AMPA receptor positive allosteric modulator – with substantially stronger AMPA binding affinity than Noopept (PMID 21476267). Unique data: benzodiazepine-withdrawal anxiety reduction in animal models without touching the GABA system; preservation of post-trauma mitochondrial oxidative phosphorylation (ATP-synthesis protection; PMID 9621180); anti-aging pro-cognitive effects in accelerated-aging models (PMID 18078032); enhanced neuroprotection when co-administered with Nimodipine. No human Phase data; rare on Western markets.
Mechanism
AMPA-PAM (glutamatergic)
Half-life
No published human data
Legal status
Russian preclinical only
Community accounts describe Nooglutyl as a nootropic with more promising anecdotal evidence than mechanistic human data. Users report a fairly quick onset within 30 minutes, producing physical stimulation, sustained mental clarity, and a functional energy feel, with duration around 3-5 hours. One user reported heavily enhanced mental clarity, focus, mild long-term memory enhancement, and mild anxiety alongside it, noting that stimulatory effects emerged at doses of 20 mg and above. Another forum user reported low toxicity, enhanced memory capacity, improved cognitive processes, and no rebound or withdrawal effects. Overall Nooglutyl is positioned as a plasticity-oriented nootropic that enhances AMPA and possibly NMDA-linked glutamatergic signaling and may indirectly tune dopamine receptor dynamics.
⚠ Not clinical evidence – based on user accounts.
Receptor profile
- AMPA glutamate receptorsStrong
- Synaptic plasticity / LTPModerate
- Antiamnesic / antihypoxic pathwaysModerate
Safety
Side effects, stop signs, contraindications
Side effects · 6
- Limited human safety data: profile based mainly on animal studies and anecdotes
- Mild anxiety and restlessness reported anecdotally (glutamatergic/stimulating character)
- Physical stimulation and overstimulation at higher doses (above ~20 mg)
- Theoretical risk typical of AMPA-enhancing compounds: headache, increased neuronal excitability
- Sleep disturbance and difficulty falling asleep if taken in late afternoon or evening
- Long-term safety unknown; chronic adverse effects not characterized
Contraindications · 5
- Pregnancy and breastfeeding: no safety data, avoid
- Epilepsy or low seizure threshold: AMPA/glutamatergic enhancement may theoretically raise seizure risk
- Anxiety disorders: the stimulating character may worsen symptoms
- Combining with other glutamatergic or stimulant nootropics requires caution (additive overstimulation)
- Not an approved drug, no human dosing standard; research chemical only, use is experimental
Related Nootropics
Same therapeutic category
FAQ
FAQ
Nooglutyl is an experimental compound developed at a Russian research institute that strengthens one of the brain's excitatory signaling systems (the AMPA receptor), so it's studied as a plasticity enhancer, meaning something meant to support the brain's ability to learn and adapt. Based on the source, this is a purely research-stage, experimental substance with no broad, reliable human data available. In practice it's a lab compound, not an established, well-tested supplement.
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Structure & chemistry
The information here is strictly for educational and scientific purposes. It does not replace medical advice or clinical consultation, and it does not encourage illegal substance or pharmaceutical use. Data is sourced. When in doubt, consult your doctor.