Noopept
Russian Rx racetam-like nootropic; small dose (10-30 mg), upregulates NGF/BDNF expression.
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Pharmacology
Contents
WHAT IS NOOPEPT?
Detailed overview
Noopept (N-phenylacetyl-L-prolylglycine ethyl ester) is a cyclic dipeptide derived from Piracetam, developed in Russia in the 1990s. Per-dose roughly 1000× more potent than Piracetam (10-30 mg/day vs. 4800 mg/day). Mechanism: AMPA + NMDA glutamatergic modulation plus NGF (nerve growth factor) and BDNF upregulation. OTC in Russia under the Noopept name; research chemical in EU/USA.
Mechanism
AMPA + NMDA + NGF/BDNF
Half-life
30-40 min (active metabolite)
Onset
15-30 min
Legal status
Russia OTC, EU/USA research
Receptor profile
- BDNF / NGFStrong
- AMPA receptorModerate
- Antioxidant systemsModerate
- Cholinergic toneWeak
Safety
Side effects, stop signs, contraindications
Side effects · 6
- Headache, typically with choline deficiency (mitigated by a choline source)
- Irritability, agitation, especially at higher doses (>40 mg/day)
- Insomnia, disturbed sleep if taken late in the day
- Overstimulation, scattered focus, amplification of the signal-to-noise noise component
- Mild dizziness or fatigue in some users
- Tolerance and reduced effect with continuous, non-cycled use
Contraindications · 5
- Pregnancy and breastfeeding (human safety data lacking)
- Bipolar spectrum disorder: risk of agitation, irritability, manic switch
- Severe renal or hepatic impairment (metabolism and clearance affected)
- Concurrent alcohol use: increased sedation
- Hypertension: blood pressure monitoring advised during use
Related Nootropics
Same therapeutic category
Studies
Related research and clinical findings
Noopept (GVS-111) cognitive effects: randomized trial
Neznamov GG, Teleshova ES.
Noopept stimulates the expression of NGF and BDNF in rat hippocampus.
Ostrovskaya RU, Gudasheva TA, Zaplina AP, et al.
The original novel nootropic and neuroprotective agent noopept.
Gudasheva TA, Voronina TA, Ostrovskaya RU, et al.
Noopept in the treatment of mild cognitive impairment in patients with stroke
Amelin AV, Iliukhina AIu, Shmonin AA.
Clinical and electroencephalographic characteristic of noopept in patients with mild cognitive impairment
Neznamov GG, Teleshova ES.
FAQ
FAQ
Noopept is a synthetic compound people generally reach for to support memory, learning and mental clarity, and it is said to kick in faster than older, related substances. Only a very small amount is needed since it is much more potent than its relatives, and it is also described as having a mild calming, anxiety-easing effect. It is worth being upfront that most of the deeper brain-protective claims come from animal studies, while the more solid human track record comes from its use as a prescription medicine in Russia.
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Structure & chemistry
The information here is strictly for educational and scientific purposes. It does not replace medical advice or clinical consultation, and it does not encourage illegal substance or pharmaceutical use. Data is sourced. When in doubt, consult your doctor.