P7C3
Aminopropyl carbazole neuroprotectant, NAMPT activator, preclinical data only.
Pharmacology
Contents
WHAT IS P7C3?
Detailed overview
P7C3 is an experimental neuroprotective aminopropyl carbazole compound identified by phenotypic screening as an enhancer of adult hippocampal neurogenesis. Its central mechanism is activation of the enzyme NAMPT (nicotinamide phosphoribosyltransferase), the rate-limiting step of the salvage pathway that converts nicotinamide into NAD+, which restores NAD+ levels in injured or stressed neurons and preserves cell survival. In rodent and non-human primate models it showed protective effects in stroke, traumatic brain injury, Parkinson- and ALS-like neurodegeneration, and depression models. There are no human clinical trials: P7C3 exists only as a laboratory research chemical, its safety in humans is unstudied, and it has never been approved for human use.
Mechanism
NAMPT activation → NAD+ salvage
Evidence
Preclinical only (no human data)
Legal status
Unapproved research chemical
Receptor profile
- NAMPT enzyme (NAD+ salvage)Strong
- Hippocampal neurogenesisStrong
- Mitochondrial functionModerate
- Neuronal apoptosis (inhibition)Moderate
Safety
Side effects, stop signs, contraindications
Side effects · 4
- No human safety data: all evidence comes from preclinical (rodent and primate) studies; the compound has never been tested in humans
- Unknown long-term safety and incomplete toxicity profile in humans
- Theoretical hepatotoxicity concern was raised for early P7C3 variants; the optimized analogues (P7C3-A20, P7C3-S243) were developed partly to reduce this
- Systemic consequences of modulating NAD+ metabolism are not characterized in humans
Contraindications · 3
- Pregnancy and breastfeeding: safety not established, avoid
- Not an approved medicine; experimental research chemical, not recommended without clinical supervision
- Known or suspected malignancy: modulating the NAMPT/NAD+ pathway warrants caution in an oncological context
Related Nootropics
Same therapeutic category
Studies
Related research and clinical findings
P7C3 neuroprotective chemicals function by activating the rate-limiting enzyme in NAD salvage
Wang G, Han T, Nijhawan D, Theodoropoulos P, Naidoo J, et al.
Development of proneurogenic, neuroprotective small molecules
MacMillan KS, Naidoo J, Liang J, Melito L, Williams NS, et al.
Discovery of a neuroprotective chemical, (S)-N-(3-(3,6-dibromo-9H-carbazol-9-yl)-2-fluoropropyl)-6-methoxypyridin-2-amine [(-)-P7C3-S243], with improved druglike properties
Naidoo J, De Jesus-Cortes H, Huntington P, Estill S, Morlock LK, et al.
Early detection of subclinical visual damage after blast-mediated TBI enables prevention of chronic visual deficit by treatment with P7C3-S243
Dutca LM, Stasheff SF, Hedberg-Buenz A, Rudd DS, Batra N, et al.
Neuroprotective efficacy of P7C3 compounds in primate hippocampus
Bauman MD, Schumann CM, Carlson EL, Taylor SL, Vazquez-Rosa E, et al.
FAQ
FAQ
Aminopropyl carbazole neuroprotectant, NAMPT activator, preclinical data only.
Telegram
Have a question about P7C3?
Reach out to us on Telegram for a personalized stack. We'll be happy to help.
Personalized consultation
Want a detailed conversation tailored to your data?
Fill out the prep intake form (your goals, training and health data), and the advisor prepares from it to give genuinely personalized guidance.
Fill out the form~5–7 min · prep questionnaire · confidential · GDPR-compliant
Structure & chemistry
The information here is strictly for educational and scientific purposes. It does not replace medical advice or clinical consultation, and it does not encourage illegal substance or pharmaceutical use. Data is sourced. When in doubt, consult your doctor.