Sabroxy
Standardized Oroxylum indicum bark extract with mild dopamine-reuptake-inhibiting and BDNF-raising flavonoids.
Pharmacology
Contents
WHAT IS SABROXY?
Detailed overview
Sabroxy is a branded, standardized extract from the bark of Oroxylum indicum (Indian trumpet tree), typically standardized to ~10% oroxylin A alongside the flavonoids baicalein and chrysin. Its main active, oroxylin A, behaves in preclinical studies as a mild dopamine transporter (DAT) reuptake inhibitor, raising synaptic dopamine while upregulating expression of the BDNF neurotrophin. The accompanying flavonoids provide antioxidant and anti-inflammatory effects that protect neurons and support mitochondrial function. Human clinical evidence is still sparse: memory, mood and neuroprotective effects are supported mainly by cell and rodent studies.
Mechanism
Mild dopamine-reuptake inhibition (DAT) + BDNF upregulation
Evidence
Mostly preclinical (sparse human data)
Legal status
Dietary supplement (standardized botanical extract)
Receptor profile
- Dopamine transporter (DAT)Moderate
- BDNF neurotrophinWeak
- Oxidative stress (antioxidant action)Moderate
- Inflammatory pathways (NF-κB / MAPK)Weak
Safety
Side effects, stop signs, contraindications
Side effects · 5
- Mild digestive upset, nausea or stomach discomfort, especially on an empty stomach
- Headache in some users during the first days of use
- Sleep disruption if dosed in the late afternoon or evening (due to the dopaminergic, stimulating character)
- Limited long-term human safety data: most evidence is preclinical (cell and animal)
- Theoretical overstimulation or restlessness when combined with other dopaminergic or stimulant agents
Contraindications · 4
- Pregnancy and breastfeeding: safety not established, avoid
- Extra caution alongside MAO inhibitors or other dopaminergic medication due to possible additive effect
- Bipolar disorder or psychosis: dopamine enhancement may theoretically worsen symptoms
- A dietary supplement, not a medicine: not intended to treat any diagnosed condition, consult a physician for medical concerns
Related Nootropics
Same therapeutic category
Studies
Related research and clinical findings
The Neuroprotective Effects of Oroxylum indicum Extract in SHSY-5Y Neuronal Cells by Upregulating BDNF Gene Expression under LPS Induced Inflammation
Sriwastva MK, et al.
Antidepressant-like activity of oroxylin A in mice models of depression: A behavioral and neurobiological characterization
Chindewa R, et al.
Oroxylin A, a flavonoid, stimulates adult neurogenesis in the hippocampal dentate gyrus region of mice
Lee S, et al.
Neuroprotective Effects of Baicalein, Wogonin, and Oroxylin A on Amyloid Beta-Induced Toxicity via NF-κB/MAPK Pathway Modulation
Sowndhararajan K, et al.
Evaluation of acute, subacute, subchronic, reproductive, and genotoxicity of a standardized extract from the bark of Oroxylum indicum
et al.
FAQ
FAQ
Standardized Oroxylum indicum bark extract with mild dopamine-reuptake-inhibiting and BDNF-raising flavonoids.
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Structure & chemistry
The information here is strictly for educational and scientific purposes. It does not replace medical advice or clinical consultation, and it does not encourage illegal substance or pharmaceutical use. Data is sourced. When in doubt, consult your doctor.