Selank
Tuftsin-analog heptapeptide (TKPRPGP). Anxiolytic + cognition without sedation, intranasal.
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Pharmacology
Contents
Related comparisons
Semax vs SelankWHAT IS SELANK?
Detailed overview
Selank is a Thr-Lys-Pro-Arg-Pro-Gly-Pro heptapeptide, a proline-stabilized analog of the natural immunomodulator Tuftsin (TKPR). Developed in Russia for anxiolytic use; intranasal spray. Mechanism: GABAergic tone elevation (subunit-selective, non-sedating) + BDNF expression + serotonergic + enkephalinergic modulation. Unlike benzodiazepines, does NOT cause sedation or dependence. Cognition parity or mild enhancement also documented. Note: peptide-library duplicate, with different framing.
Mechanism
Tuftsin analog, GABA + BDNF
Half-life
20-30 min (intranasal)
Onset
5-15 min
Legal status
Russia Rx, EU/USA research
Receptor profile
- Tuftsin / immune peptide pathwayModerate
- BDNF / GABAModerate
- EnkephalinaseModerate
Safety
Side effects, stop signs, contraindications
Side effects · 6
- Nasal mucosa irritation, mild stinging or dryness at the intranasal application site
- Mild headache or dizziness, especially with initial doses
- Fatigue or mild lethargy in some users, despite the non-sedating profile
- Irritability or mood fluctuation, particularly on discontinuation
- Rare allergic or hypersensitivity reaction due to the peptide structure
- Some users report no perceptible effect at all (variable response)
Contraindications · 6
- Pregnancy and breastfeeding: no peptide-specific human safety data, avoid
- Known hypersensitivity to Selank or Tuftsin analogs
- Active autoimmune disease: caution due to the immunomodulatory (Tuftsin-derived) action
- Not recommended as monotherapy in severe depression, specialist supervision required
- Caution with benzodiazepines and alcohol due to theoretical additive GABAergic effect
- With SSRIs only under clinical monitoring, due to serotonergic modulation
Related Nootropics
Same therapeutic category
Studies
Related research and clinical findings
Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia.
Zozulia AA, Neznamov GG, Siuniakov TS, et al.
A comparison of the anxiolytic effect and tolerability of selank and phenazepam in the treatment of anxiety disorders.
Medvedev VE, Tereshchenko ON, Israelian AIu, et al.
FAQ
FAQ
Selank is a lab-developed peptide (originally from Russian research) taken as a nasal spray, used mainly to reduce anxiety without causing drowsiness or dependence. In clinical trials for generalized anxiety disorder it showed efficacy comparable to sedative anti-anxiety medication, without the memory impairment or dependence risk, and it may also give a mild mood lift and help protect thinking under stress.
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Structure & chemistry
The information here is strictly for educational and scientific purposes. It does not replace medical advice or clinical consultation, and it does not encourage illegal substance or pharmaceutical use. Data is sourced. When in doubt, consult your doctor.