Unifiram
Ampakine (DM-232), alkynyl variant of Sunifiram, AMPA-PAM.
Pharmacology
Contents
Related comparisons
Sunifiram vs UnifiramWHAT IS UNIFIRAM?
Detailed overview
Unifiram (DM-232) is a designed alkynyl analog of Sunifiram (DM-235), with similar sub-mg in vivo activity in rat anti-amnestic models. Interestingly it does NOT directly act as an AMPA-PAM (unlike classical ampakines) – instead it improves glutamatergic signal-processing efficiency, enhancing how memory circuits respond to glutamate. Indirect activation at the NMDA glycine site + acetylcholine release modulation in cerebral cortex. Long-lasting hippocampal LTP elevation. Less activating than Sunifiram, more pro-cognitive profile; data report no adverse effects in studied models. No human data exist.
Mechanism
AMPA-PAM (Sunifiram-like)
Half-life
No human data
Legal status
Investigational, not approved
Receptor profile
- AMPA receptorsStrong
- Hippocampal excitatory transmissionStrong
- Cholinergic systemModerate
Safety
Side effects, stop signs, contraindications
Side effects · 6
- No human safety data, only preclinical (rodent) and anecdotal reports
- Anxiety, tension and restlessness (highly individual response)
- Stimulating, energizing effect that can tip into overstimulation at higher doses
- Possible sleep disruption if taken late in the day (stimulant-like profile)
- Headache or agitation theoretically arising from glutamatergic (AMPA/NMDA) modulation
- Unknown long-term safety, unknown tolerance and risk profile
Contraindications · 5
- Pregnancy and breastfeeding: strictly avoid due to lack of human data
- Caution with anxiety disorders or panic tendency (the stimulating effect may worsen them)
- Epilepsy or seizure-threshold disorders: glutamatergic excitation may theoretically raise seizure risk
- Combined with other stimulants or caffeine, increased agitation and anxiety are possible
- Experimental, nowhere-approved substance; no established safe dosing or drug-interaction profile
Related Nootropics
Same therapeutic category
FAQ
FAQ
Unifiram is an experimental, lab-designed compound developed as a relative of the nootropic Sunifiram, and it showed memory-enhancing effects at very low doses in animal studies. Importantly, there is essentially no human research on it, so this is a purely research-stage substance with very little data on its real-world effects or safety in people.
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Structure & chemistry
The information here is strictly for educational and scientific purposes. It does not replace medical advice or clinical consultation, and it does not encourage illegal substance or pharmaceutical use. Data is sourced. When in doubt, consult your doctor.