Vinburnine
Eburnamine-family vinca alkaloid cerebral vasodilator with a neuroprotective, antihypoxic profile.
Pharmacology
Contents
WHAT IS VINBURNINE?
Detailed overview
Vinburnine (eburnamonine) is an indole alkaloid of the eburnamine-vincamine family that was marketed in France as Cervoxan for cerebral circulation. As a cerebral vasodilator it widens brain blood vessels, improves circulation and oxygen delivery, and increases the resilience of nerve tissue to low oxygen (hypoxia). Its proposed mechanism involves phosphodiesterase modulation and ion-channel effects, and experimental data also show it allosterically modulates muscarinic acetylcholine receptors. Most evidence comes from preclinical work and older clinical observation: modern large randomized trials are lacking and the compound is not FDA-approved.
Mechanism
Cerebral vasodilation + PDE modulation
Half-life
Short, a few hours (like related vinca alkaloids)
Legal status
Medicine in some markets (Cervoxan), not FDA-approved
Receptor profile
- Phosphodiesterase (PDE)Moderate
- Cerebral blood flowModerate
- Muscarinic acetylcholine receptors (allosteric)Moderate
- Neuronal metabolism / antihypoxiaWeak
Safety
Side effects, stop signs, contraindications
Side effects · 5
- Dizziness, particularly on standing due to lowered blood pressure
- Low blood pressure (hypotension) from the vasodilatory effect
- Occasional gastrointestinal upset, nausea
- Rare skin reactions: fixed drug eruption reported in a case report
- Limited safety data from large clinical trials
Contraindications · 4
- Pregnancy and breastfeeding: safety not established, avoid
- Low blood pressure or hypotension tendency: the vasodilatory effect may worsen it
- Co-administration with other blood-pressure-lowering agents: additive hypotension
- Known hypersensitivity to vinca alkaloids or the compound
Related Nootropics
Same therapeutic category
Studies
Related research and clinical findings
Eburnamine derivatives and the brain
Zsilla G, Vizi ES
Effects of vinburnine on experimental models of learning and memory impairments
Nemeth EF, Fejes-Toth AN, et al.
Vinburnine decelerates [3H]N-methylscopolamine binding to recombinant human muscarinic M1-M4 acetylcholine receptors
Tuček S, et al.
Positive allosteric action of eburnamonine on cardiac muscarinic acetylcholine receptors
Jakubík J, Tuček S
Red blood cell metabolism and hemoglobin oxygen affinity. Effect of vinburnine on normobaric hypoxic rats
Fiorani M, et al.
[The effects of the acute administration of vinburnine on blood rheology, oxygen transport and regional circulation under normal conditions and in hypoxemia. In vivo research]
et al.
FAQ
FAQ
Eburnamine-family vinca alkaloid cerebral vasodilator with a neuroprotective, antihypoxic profile.
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Structure & chemistry
The information here is strictly for educational and scientific purposes. It does not replace medical advice or clinical consultation, and it does not encourage illegal substance or pharmaceutical use. Data is sourced. When in doubt, consult your doctor.