PreclinicalResearch compound

5‑Amino‑1MQ

NNMT inhibitor, metabolic-enhancing small molecule

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5-Amino-1MQ vial

WHAT IS 5-AMINO-1MQ?

Detailed overview

5-Amino-1MQ is a small-molecule NNMT inhibitor; in preclinical obesity models it reduces adipose tissue and improves insulin sensitivity.

Type

NNMT inhibitor (non-peptide)

Status

Preclinical

Route

Oral

Storage

2–8°C

Source

Placeholder, image later

Metabolic support

Glucose and lipid metabolism shift favorably: insulin sensitivity improves, glycemic swings and HbA1c drop, while LDL and triglycerides normalize. Body composition refines, fat mass decreases, lean mass is preserved or grows. Appetite is regulated both centrally and peripherally (GLP-1 / GIP / glucagon pathways), so caloric intake settles into a sustainable range without constant willpower. Energy expenditure and thermogenesis rise modestly.

Cellular renewal

The peptide acts on several aging fundamentals: telomerase activation slows telomere shortening; oxidative stress drops (Nrf2 / glutathione system); gene-expression patterns epigenetically normalize. Mitochondrial energy production improves, tissue-specific stem-cell activity is supported. On skin: collagen I/III synthesis rises, wrinkle depth shrinks, hydration and elasticity improve. Long-term, biomarkers (CRP, glucose, lipids) show younger patterns and epigenetic age can slow.

Data console

Lab data

/lab/molecular-data.jsonLIVE
> ClassificationNNMT inhibitor (non-peptide)
> StructureN/A
> Molecular weightN/A
> Target area-
> Storage2–8°C
> Stability~30 days reconstituted

Research indications

Investigated uses and mechanisms

Weight regulation

Reduced appetite and increased energy expenditure via GLP-1 / GIP / glucagon agonism.

Type 2 diabetes

Improved insulin sensitivity and HbA1c reduction in clinical trials.

Cardiometabolic profile

Favorable shifts in lipid profile and blood pressure.

Quality indicators

How to recognize a pure peptide

Purity markers

3

  • Clear oil

    Clear or slightly yellow (MCT/sesame/castor oil), particle-free.

  • Vial integrity

    Glass intact, rubber stopper undamaged, aluminum crimp tight.

  • Label + COA

    Manufacturer + LOT + expiry legible; independent HPLC analysis on active content.

Use caution

1

  • BA/BB carrier blend

    Excessive benzyl alcohol (>3%) raises PIP risk; verify with UGL manufacturers.

Do not use

2

  • Cloudiness / sediment

    Floating particles, cloudiness, or sediment = HARD NO.

  • Damaged glass / stopper

    Cracked vial or loose stopper, sterility compromised.

Interactions & stacks

What to combine and what to avoid

Humanin

Synergistic

Mitochondrial-derived peptide, neuro & metabolic protection

MOTS-c

Synergistic

Mitochondrial peptide, metabolism and AMPK activation

Berberine

Synergistic

Insulin sensitivity + GLP-1 effects combine well.

Vitamin C / Zinc / B-complex

Synergistic

Supports collagen synthesis and antioxidant capacity.

Metformin

Complementary

Many clinical protocols combine them, supervision advised.

Caffeine

Requires timing

Compatible with morning dosing; avoid late-day stacking.

NSAIDs (Ibuprofen, ASA)

Use caution

Long-term concurrent use may blunt regenerative effects.

Alcohol

Avoid

Reduces recovery and increases side-effect risk.

Safety

Side effects, stop signs, contraindications

Side effects · 7

  • Nausea, headache, especially during titration
  • Appetite and bowel-motility shifts
  • Local skin reaction at injection site
  • Transient blood-sugar variability (esp. in diabetics)
  • Mild heart-rate increase
  • PIP (post-injection pain) – especially propionate, trenbolone-ace, or high-BA blends
  • Injection-site reaction: lumps, redness, warmth, tenderness

Contraindications · 5

  • Pregnancy and breastfeeding
  • Active malignancy
  • Known allergy to the peptide or its components
  • Severe hepatic or renal impairment (medical consultation required)
  • Age under 18

Related Peptides

Same therapeutic category

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MolekulaX Editorial Team·Source-verified · PubMed · FDA · EMA
Updated: June 19, 2026

The information here is strictly for educational and scientific purposes. It does not replace medical advice or clinical consultation, and it does not encourage illegal substance or pharmaceutical use. Data is sourced. When in doubt, consult your doctor.