CJC‑1295 / Ipamorelin
GHRH analog + selective ghrelin mimetic combo for synergistic GH pulse
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WHAT IS CJC-1295 / IPAMORELIN?
Detailed overview
CJC-1295 (a modified GHRH 1-29) combined with Ipamorelin (a selective GHRP / ghrelin-receptor agonist) amplifies pulsatile growth hormone (GH) release through two different receptors, the classic "GHRH + GHRP" stack. CJC-1295 acts on pituitary GHRH receptors; ipamorelin acts on the ghrelin receptor. Their signals synergise, and ipamorelin's selectivity keeps cortisol/prolactin rises minimal.
Type
GHRH + GHRP combo
Structure
CJC-1295 (30 aa) + Ipamorelin (5 aa)
Molecular weight
~3367 + ~712 Da
Target area
Pulsatile GH increase (IGF-1)
Storage
2–8°C (reconstituted)
Stability
25–30 days (reconstituted)
Growth hormone release
The peptide acts on pituitary GHRH or GHS receptors, producing a **physiological, pulsatile GH release**, unlike synthetic rHGH, which keeps levels flat and leads to desensitization. IGF-1 rises into the upper-normal range, driving recovery, muscle protein synthesis, lipolysis and skin quality. Deep-sleep phases lengthen; collagen and bone-matrix synthesis activate. The effect is reversible and does not suppress the endogenous GH axis.
This stack contains the following peptides
Data console
Lab data
Research indications
Investigated uses and mechanisms
Growth hormone release
Mimics physiological pulsatile GH secretion; IGF-1 rise.
Recovery & body comp
Muscle mass gain, fat reduction, post-workout recovery.
Sleep quality
Deep-sleep (N3) phases lengthen.
Reconstitution
How to prepare, step by step
Important
Sterile technique required. Use bacteriostatic water (BAC) only. Never distilled or tap water.
- 01
Remove the vial and bacteriostatic water (BAC) from refrigeration; let them reach room temp for 5 minutes.
- 02
Wipe both vial stoppers with an alcohol swab.
- 03
Draw 2 ml of BAC water into a sterile syringe (typical for the 5 mg vial).
- 04
Inject slowly down the side of the vial, do NOT spray directly onto the peptide powder.
- 05
Swirl gently in a circular motion until dissolved (~30 s), do not shake.
- 06
Wait for the solution to become clear. If sediment or discoloration appears, discard it.
- 07
Label the vial with reconstitution date and concentration.
- 08
Store at 2–8 °C, protected from light. Inspect visually before each use.
Quality indicators
How to recognize a pure peptide
Purity markers
3Clear oil
Clear or slightly yellow (MCT/sesame/castor oil), particle-free.
Vial integrity
Glass intact, rubber stopper undamaged, aluminum crimp tight.
Label + COA
Manufacturer + LOT + expiry legible; independent HPLC analysis on active content.
Use caution
1BA/BB carrier blend
Excessive benzyl alcohol (>3%) raises PIP risk; verify with UGL manufacturers.
Do not use
2Cloudiness / sediment
Floating particles, cloudiness, or sediment = HARD NO.
Damaged glass / stopper
Cracked vial or loose stopper, sterility compromised.
Interactions & stacks
What to combine and what to avoid
CJC-1295
SynergisticGHRH analog: sustained growth hormone stimulation
Ipamorelin
SynergisticSelective GH secretagogue: without cortisol elevation
Ipamorelin
SynergisticGHRH + GHRP, classic pulsatile GH stack.
Vitamin C / Zinc / B-complex
SynergisticSupports collagen synthesis and antioxidant capacity.
Caffeine
Requires timingCompatible with morning dosing; avoid late-day stacking.
Insulin
Use cautionContinuous glucose monitoring required.
NSAIDs (Ibuprofen, ASA)
Use cautionLong-term concurrent use may blunt regenerative effects.
Alcohol
AvoidReduces recovery and increases side-effect risk.
Safety
Side effects, stop signs, contraindications
Side effects · 6
- Water retention, mild edema
- Wrist / joint stiffness (carpal-tunnel-like)
- Transient blood-glucose increase
- Mild prolactin / cortisol increase (some peptides)
- PIP (post-injection pain) – especially propionate, trenbolone-ace, or high-BA blends
- Injection-site reaction: lumps, redness, warmth, tenderness
Contraindications · 5
- Pregnancy and breastfeeding
- Active malignancy
- Known allergy to the peptide or its components
- Severe hepatic or renal impairment (medical consultation required)
- Age under 18
Related Peptides
Same therapeutic category
Studies
Related research and clinical findings
Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults.
Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohman LA
CJC-1295 produces dose-dependent, sustained increases in GH and IGF-1 in healthy adults.
Ipamorelin, the first selective growth hormone secretagogue
Raun K, Hansen BS, Johansen NL, et al.
Ipamorelin selectively stimulates GH secretion without significant ACTH/cortisol elevation.
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The information here is strictly for educational and scientific purposes. It does not replace medical advice or clinical consultation, and it does not encourage illegal substance or pharmaceutical use. Data is sourced. When in doubt, consult your doctor.