IGF‑1 LR3
Long-half-life IGF-1 analog, anabolic signalling
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WHAT IS IGF-1 LR3?
Detailed overview
IGF-1 LR3 (Long Arg3 IGF-1) is a modified, longer-half-life IGF-1 analog with reduced IGFBP binding, leaving more in the active free form.
Type
IGF-1 analog
Structure
83 aa, Arg3 substitution + N-terminal extension
Status
Research
Route
SC
Storage
2–8°C
Source
Placeholder, image later
Growth hormone release
The peptide acts on pituitary GHRH or GHS receptors, producing a physiological, pulsatile GH release, unlike synthetic rHGH, which keeps levels flat and leads to desensitization. IGF-1 rises into the upper-normal range, driving recovery, muscle protein synthesis, lipolysis and skin quality. Deep-sleep phases lengthen; collagen and bone-matrix synthesis activate. The effect is reversible and does not suppress the endogenous GH axis.
Tissue regeneration
Tendons, muscles, ligaments, GI mucosa and skin heal faster thanks to direct cell-level signaling: it activates fibroblast migration, angiogenesis (VEGF pathway) and reduces pro-inflammatory cytokines (IL-6, TNF-α). Chronic, slow-healing injuries see functional improvement; pain and swelling drop. Post-workout recovery windows shorten by 30–50%, allowing more training volume. Effects are documented even in enthesopathy, tendinitis and GI ulcers.
Data console
Lab data
Research indications
Investigated uses and mechanisms
Growth hormone release
Mimics physiological pulsatile GH secretion; IGF-1 rise.
Recovery & body comp
Muscle mass gain, fat reduction, post-workout recovery.
Sleep quality
Deep-sleep (N3) phases lengthen.
Reconstitution
How to prepare, step by step
Important
Sterile technique required. Use bacteriostatic water (BAC) only. Never distilled or tap water.
- 01
Remove the vial and bacteriostatic water (BAC) from refrigeration; let them reach room temp for 5 minutes.
- 02
Wipe both vial stoppers with an alcohol swab.
- 03
Draw 1 ml of BAC water into a sterile syringe (typical for the 1 mg vial).
- 04
Inject slowly down the side of the vial, do NOT spray directly onto the peptide powder.
- 05
Swirl gently in a circular motion until dissolved (~30 s), do not shake.
- 06
Wait for the solution to become clear. If sediment or discoloration appears, discard it.
- 07
Label the vial with reconstitution date and concentration.
- 08
Store at 2–8 °C, protected from light. Inspect visually before each use.
Quality indicators
How to recognize a pure peptide
Purity markers
4White / off-white powder
Typical appearance of sterile lyophilized peptide.
Comes with COA (Certificate of Analysis)
Independent lab analysis, ≥98% purity.
Intact, sealed vial
Rubber stopper + aluminum crimp intact, ensuring sterility.
Dissolves clear
Clear solution after reconstitution, no sediment.
Use caution
1Storage temperature
Extended room-temp exposure may reduce potency.
Do not use
2Discoloration / sediment
Yellow, cloudy or particulate solution, indicates degradation, do not use.
Damaged packaging
Cracked vial or loose cap, sterility compromised, discard.
Interactions & stacks
What to combine and what to avoid
HCG (fertilitás)
SynergisticLH-receptor agonist glycoprotein: fertility induction and HPTA recovery
GHK-Cu
SynergisticCopper peptide: skin regeneration and epigenetic modulation
Ipamorelin
SynergisticGHRH + GHRP, classic pulsatile GH stack.
Vitamin C / Zinc / B-complex
SynergisticSupports collagen synthesis and antioxidant capacity.
Caffeine
Requires timingCompatible with morning dosing; avoid late-day stacking.
Insulin
Use cautionContinuous glucose monitoring required.
NSAIDs (Ibuprofen, ASA)
Use cautionLong-term concurrent use may blunt regenerative effects.
Alcohol
AvoidReduces recovery and increases side-effect risk.
Safety
Side effects, stop signs, contraindications
Side effects · 5
- Injection-site redness, itching
- Water retention, mild edema
- Wrist / joint stiffness (carpal-tunnel-like)
- Transient blood-glucose increase
- Mild prolactin / cortisol increase (some peptides)
Contraindications · 5
- Pregnancy and breastfeeding
- Active malignancy
- Known allergy to the peptide or its components
- Severe hepatic or renal impairment (medical consultation required)
- Age under 18
Related Peptides
Same therapeutic category
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The information here is strictly for educational and scientific purposes. It does not replace medical advice or clinical consultation, and it does not encourage illegal substance or pharmaceutical use. Data is sourced. When in doubt, consult your doctor.