PreclinicalResearch compound

IGF‑1 LR3

Long-half-life IGF-1 analog, anabolic signalling

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IGF-1 LR3 vial

WHAT IS IGF-1 LR3?

Detailed overview

IGF-1 LR3 (Long Arg3 IGF-1) is a modified, longer-half-life IGF-1 analog with reduced IGFBP binding, leaving more in the active free form.

Type

IGF-1 analog

Structure

83 aa, Arg3 substitution + N-terminal extension

Status

Research

Route

SC

Storage

2–8°C

Source

Placeholder, image later

Growth hormone release

The peptide acts on pituitary GHRH or GHS receptors, producing a **physiological, pulsatile GH release**, unlike synthetic rHGH, which keeps levels flat and leads to desensitization. IGF-1 rises into the upper-normal range, driving recovery, muscle protein synthesis, lipolysis and skin quality. Deep-sleep phases lengthen; collagen and bone-matrix synthesis activate. The effect is reversible and does not suppress the endogenous GH axis.

Tissue regeneration

Tendons, muscles, ligaments, GI mucosa and skin heal faster thanks to direct cell-level signaling: it activates fibroblast migration, angiogenesis (VEGF pathway) and reduces pro-inflammatory cytokines (IL-6, TNF-α). Chronic, slow-healing injuries see functional improvement; pain and swelling drop. Post-workout recovery windows shorten by 30–50%, allowing more training volume. Effects are documented even in enthesopathy, tendinitis and GI ulcers.

Data console

Lab data

/lab/molecular-data.jsonLIVE
> ClassificationIGF-1 analog
> Structure83 aa, Arg3 substitution + N-terminal extension
> Molecular weightN/A
> Target area-
> Storage2–8°C
> Stability~30 days reconstituted

Research indications

Investigated uses and mechanisms

Growth hormone release

Mimics physiological pulsatile GH secretion; IGF-1 rise.

Recovery & body comp

Muscle mass gain, fat reduction, post-workout recovery.

Sleep quality

Deep-sleep (N3) phases lengthen.

Reconstitution

How to prepare, step by step

Important

Sterile technique required. Use bacteriostatic water (BAC) only. Never distilled or tap water.

  1. 01

    Remove the vial and bacteriostatic water (BAC) from refrigeration; let them reach room temp for 5 minutes.

  2. 02

    Wipe both vial stoppers with an alcohol swab.

  3. 03

    Draw 1 ml of BAC water into a sterile syringe (typical for the 1 mg vial).

  4. 04

    Inject slowly down the side of the vial, do NOT spray directly onto the peptide powder.

  5. 05

    Swirl gently in a circular motion until dissolved (~30 s), do not shake.

  6. 06

    Wait for the solution to become clear. If sediment or discoloration appears, discard it.

  7. 07

    Label the vial with reconstitution date and concentration.

  8. 08

    Store at 2–8 °C, protected from light. Inspect visually before each use.

Quality indicators

How to recognize a pure peptide

Purity markers

3

  • Clear oil

    Clear or slightly yellow (MCT/sesame/castor oil), particle-free.

  • Vial integrity

    Glass intact, rubber stopper undamaged, aluminum crimp tight.

  • Label + COA

    Manufacturer + LOT + expiry legible; independent HPLC analysis on active content.

Use caution

1

  • BA/BB carrier blend

    Excessive benzyl alcohol (>3%) raises PIP risk; verify with UGL manufacturers.

Do not use

2

  • Cloudiness / sediment

    Floating particles, cloudiness, or sediment = HARD NO.

  • Damaged glass / stopper

    Cracked vial or loose stopper, sterility compromised.

Interactions & stacks

What to combine and what to avoid

HCG (fertilitás)

Synergistic

LH-receptor agonist glycoprotein: fertility induction and HPTA recovery

GHK-Cu

Synergistic

Copper peptide: skin regeneration and epigenetic modulation

Ipamorelin

Synergistic

GHRH + GHRP, classic pulsatile GH stack.

Vitamin C / Zinc / B-complex

Synergistic

Supports collagen synthesis and antioxidant capacity.

Caffeine

Requires timing

Compatible with morning dosing; avoid late-day stacking.

Insulin

Use caution

Continuous glucose monitoring required.

NSAIDs (Ibuprofen, ASA)

Use caution

Long-term concurrent use may blunt regenerative effects.

Alcohol

Avoid

Reduces recovery and increases side-effect risk.

Safety

Side effects, stop signs, contraindications

Side effects · 6

  • Water retention, mild edema
  • Wrist / joint stiffness (carpal-tunnel-like)
  • Transient blood-glucose increase
  • Mild prolactin / cortisol increase (some peptides)
  • PIP (post-injection pain) – especially propionate, trenbolone-ace, or high-BA blends
  • Injection-site reaction: lumps, redness, warmth, tenderness

Contraindications · 5

  • Pregnancy and breastfeeding
  • Active malignancy
  • Known allergy to the peptide or its components
  • Severe hepatic or renal impairment (medical consultation required)
  • Age under 18

Related Peptides

Same therapeutic category

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MolekulaX Editorial Team·Source-verified · PubMed · FDA · EMA
Updated: June 2, 2026

The information here is strictly for educational and scientific purposes. It does not replace medical advice or clinical consultation, and it does not encourage illegal substance or pharmaceutical use. Data is sourced. When in doubt, consult your doctor.