PreclinicalResearch compound

KPV

α-MSH C-terminal tripeptide, anti-inflammatory

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KPV vial

WHAT IS KPV?

Detailed overview

KPV (Lys-Pro-Val) is the C-terminal tripeptide of α-MSH; it shows anti-inflammatory activity in IBD and skin models via NF-κB inhibition.

Type

α-MSH fragment

Structure

Lys-Pro-Val

Status

Research

Route

SC or oral

Storage

2–8°C

Source

Placeholder, image later

GI tract protection

Directly stimulates gut-mucosal regeneration: epithelial renewal, tight-junction restoration, mucosal thickness normalization. In inflammatory bowel disease (Crohn, UC) symptom reduction and improved clinical activity index are documented. In functional GI disorders (IBS, FD) bloating, pain and discomfort drop. Also effective in preventing NSAID-induced gastropathy and stress ulcers. Microbiome-friendly anti-inflammatory profile.

Immune modulation

Bidirectional immune regulation: in underactive immunity it supports T-cell maturation, NK activity and antibody response, while in chronic overactive (autoimmune) processes it drives Treg activation and inflammation reduction. Thymic regeneration (especially with age), faster flu / viral clearance and reduced chronic infections are documented. CRP, IL-6 and other inflammatory markers measurably drop with longer use. Not a replacement for immunosuppressives, complementary.

Data console

Lab data

/lab/molecular-data.jsonLIVE
> Classificationα-MSH fragment
> StructureLys-Pro-Val
> Molecular weightN/A
> Target area-
> Storage2–8°C
> Stability~30 days reconstituted

Research indications

Investigated uses and mechanisms

Inflammatory bowel disease

Crohn / ulcerative colitis symptom reduction; mucosal regeneration.

Functional GI disorders

IBS / FD symptom improvement.

Reconstitution

How to prepare, step by step

Important

Sterile technique required. Use bacteriostatic water (BAC) only. Never distilled or tap water.

  1. 01

    Remove the vial and bacteriostatic water (BAC) from refrigeration; let them reach room temp for 5 minutes.

  2. 02

    Wipe both vial stoppers with an alcohol swab.

  3. 03

    Draw 2 ml of BAC water into a sterile syringe (typical for the 5 mg vial).

  4. 04

    Inject slowly down the side of the vial, do NOT spray directly onto the peptide powder.

  5. 05

    Swirl gently in a circular motion until dissolved (~30 s), do not shake.

  6. 06

    Wait for the solution to become clear. If sediment or discoloration appears, discard it.

  7. 07

    Label the vial with reconstitution date and concentration.

  8. 08

    Store at 2–8 °C, protected from light. Inspect visually before each use.

Quality indicators

How to recognize a pure peptide

Purity markers

3

  • Clear oil

    Clear or slightly yellow (MCT/sesame/castor oil), particle-free.

  • Vial integrity

    Glass intact, rubber stopper undamaged, aluminum crimp tight.

  • Label + COA

    Manufacturer + LOT + expiry legible; independent HPLC analysis on active content.

Use caution

1

  • BA/BB carrier blend

    Excessive benzyl alcohol (>3%) raises PIP risk; verify with UGL manufacturers.

Do not use

2

  • Cloudiness / sediment

    Floating particles, cloudiness, or sediment = HARD NO.

  • Damaged glass / stopper

    Cracked vial or loose stopper, sterility compromised.

Interactions & stacks

What to combine and what to avoid

BPC-157

Synergistic

Gastric pentadecapeptide: tissue regeneration and healing

Thymosin Alpha-1

Synergistic

28-aa immunomodulatory peptide, T-cell activation

L-Glutamine

Synergistic

Supports gut-mucosal healing.

Vitamin C / Zinc / B-complex

Synergistic

Supports collagen synthesis and antioxidant capacity.

Caffeine

Requires timing

Compatible with morning dosing; avoid late-day stacking.

NSAIDs (Ibuprofen, ASA)

Use caution

Long-term concurrent use may blunt regenerative effects.

Alcohol

Avoid

Reduces recovery and increases side-effect risk.

Safety

Side effects, stop signs, contraindications

Side effects · 4

  • Transient bloating
  • Appetite shift
  • PIP (post-injection pain) – especially propionate, trenbolone-ace, or high-BA blends
  • Injection-site reaction: lumps, redness, warmth, tenderness

Contraindications · 5

  • Pregnancy and breastfeeding
  • Active malignancy
  • Known allergy to the peptide or its components
  • Severe hepatic or renal impairment (medical consultation required)
  • Age under 18

Related Peptides

Same therapeutic category

Studies

Related research and clinical findings

Research
Endocr Rev · 2008

Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects in vitro and in vivo.

Brzoska T, Luger TA, Maaser C, et al.

KPV reduces inflammatory cytokines and clinical severity in IBD and skin models.

PMID: 18612139Open

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MolekulaX Editorial Team·Source-verified · PubMed · FDA · EMA
Updated: June 2, 2026

The information here is strictly for educational and scientific purposes. It does not replace medical advice or clinical consultation, and it does not encourage illegal substance or pharmaceutical use. Data is sourced. When in doubt, consult your doctor.