PreclinicalResearch compound

LL‑37 (Cathelicidin)

Antimicrobial peptide, wound healing & immunity

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LL-37 (Cathelicidin) vial

WHAT IS LL-37 (CATHELICIDIN)?

Detailed overview

LL-37 is the only human cathelicidin; a broad-spectrum antimicrobial, wound-healing and immunomodulatory peptide.

Type

Cathelicidin

Structure

37 aa, α-helical

Status

Preclinical/Phase 1-2

Route

Topical or SC

Storage

2–8°C

Source

Placeholder, image later

Immune modulation

Bidirectional immune regulation: in underactive immunity it supports T-cell maturation, NK activity and antibody response, while in chronic overactive (autoimmune) processes it drives Treg activation and inflammation reduction. Thymic regeneration (especially with age), faster flu / viral clearance and reduced chronic infections are documented. CRP, IL-6 and other inflammatory markers measurably drop with longer use. Not a replacement for immunosuppressives, complementary.

Tissue regeneration

Tendons, muscles, ligaments, GI mucosa and skin heal faster thanks to direct cell-level signaling: it activates fibroblast migration, angiogenesis (VEGF pathway) and reduces pro-inflammatory cytokines (IL-6, TNF-α). Chronic, slow-healing injuries see functional improvement; pain and swelling drop. Post-workout recovery windows shorten by 30–50%, allowing more training volume. Effects are documented even in enthesopathy, tendinitis and GI ulcers.

Data console

Lab data

/lab/molecular-data.jsonLIVE
> ClassificationCathelicidin
> Structure37 aa, α-helical
> Molecular weightN/A
> Target area-
> Storage2–8°C
> Stability~30 days reconstituted

Research indications

Investigated uses and mechanisms

T-cell maturation

Maturation and function of thymus-derived T lymphocytes.

NK-cell activity

Natural-killer cell activity boost.

Inflammation regulation

Bidirectional immune regulation in chronic inflammation.

Reconstitution

How to prepare, step by step

Important

Sterile technique required. Use bacteriostatic water (BAC) only. Never distilled or tap water.

  1. 01

    Remove the vial and bacteriostatic water (BAC) from refrigeration; let them reach room temp for 5 minutes.

  2. 02

    Wipe both vial stoppers with an alcohol swab.

  3. 03

    Draw 2 ml of BAC water into a sterile syringe (typical for the 5 mg vial).

  4. 04

    Inject slowly down the side of the vial, do NOT spray directly onto the peptide powder.

  5. 05

    Swirl gently in a circular motion until dissolved (~30 s), do not shake.

  6. 06

    Wait for the solution to become clear. If sediment or discoloration appears, discard it.

  7. 07

    Label the vial with reconstitution date and concentration.

  8. 08

    Store at 2–8 °C, protected from light. Inspect visually before each use.

Quality indicators

How to recognize a pure peptide

Purity markers

3

  • Clear oil

    Clear or slightly yellow (MCT/sesame/castor oil), particle-free.

  • Vial integrity

    Glass intact, rubber stopper undamaged, aluminum crimp tight.

  • Label + COA

    Manufacturer + LOT + expiry legible; independent HPLC analysis on active content.

Use caution

1

  • BA/BB carrier blend

    Excessive benzyl alcohol (>3%) raises PIP risk; verify with UGL manufacturers.

Do not use

2

  • Cloudiness / sediment

    Floating particles, cloudiness, or sediment = HARD NO.

  • Damaged glass / stopper

    Cracked vial or loose stopper, sterility compromised.

Interactions & stacks

What to combine and what to avoid

GLOW

Synergistic

Multi-peptide stack: GHK-Cu + BPC-157 + TB-500 for skin and tissue regeneration

GHK-Cu

Synergistic

Copper peptide: skin regeneration and epigenetic modulation

Vitamin D3

Synergistic

T-cell maturation + immune modulation jointly improved.

Vitamin C / Zinc / B-complex

Synergistic

Supports collagen synthesis and antioxidant capacity.

Caffeine

Requires timing

Compatible with morning dosing; avoid late-day stacking.

NSAIDs (Ibuprofen, ASA)

Use caution

Long-term concurrent use may blunt regenerative effects.

Alcohol

Avoid

Reduces recovery and increases side-effect risk.

Safety

Side effects, stop signs, contraindications

Side effects · 4

  • Transient flu-like symptoms
  • Mild fever after first doses
  • PIP (post-injection pain) – especially propionate, trenbolone-ace, or high-BA blends
  • Injection-site reaction: lumps, redness, warmth, tenderness

Contraindications · 5

  • Pregnancy and breastfeeding
  • Active malignancy
  • Known allergy to the peptide or its components
  • Severe hepatic or renal impairment (medical consultation required)
  • Age under 18

Related Peptides

Same therapeutic category

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MolekulaX Editorial Team·Source-verified · PubMed · FDA · EMA
Updated: June 2, 2026

The information here is strictly for educational and scientific purposes. It does not replace medical advice or clinical consultation, and it does not encourage illegal substance or pharmaceutical use. Data is sourced. When in doubt, consult your doctor.