NAD+
Nicotinamide adenine dinucleotide, cell energy & sirtuins
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WHAT IS NAD+?
Detailed overview
NAD+ is a key redox cofactor and sirtuin substrate. Its age-related decline drives interest in IV anti-ageing protocols; oral precursors (NMN, NR) are more practical.
Type
Coenzyme / precursor
Status
Supplement (NMN/NR)
Route
IV, SC, oral (NMN/NR)
Storage
2–8°C
Source
Placeholder, image later
Cellular renewal
The peptide acts on several aging fundamentals: telomerase activation slows telomere shortening; oxidative stress drops (Nrf2 / glutathione system); gene-expression patterns epigenetically normalize. Mitochondrial energy production improves, tissue-specific stem-cell activity is supported. On skin: collagen I/III synthesis rises, wrinkle depth shrinks, hydration and elasticity improve. Long-term, biomarkers (CRP, glucose, lipids) show younger patterns and epigenetic age can slow.
Metabolic support
Glucose and lipid metabolism shift favorably: insulin sensitivity improves, glycemic swings and HbA1c drop, while LDL and triglycerides normalize. Body composition refines, fat mass decreases, lean mass is preserved or grows. Appetite is regulated both centrally and peripherally (GLP-1 / GIP / glucagon pathways), so caloric intake settles into a sustainable range without constant willpower. Energy expenditure and thermogenesis rise modestly.
Data console
Lab data
Research indications
Investigated uses and mechanisms
Cellular renewal
Telomerase activation; preserves cell-division capacity.
Epigenetic modulation
Normalizes age-specific gene-expression patterns.
Oxidative stress
Increases antioxidant capacity; mitochondrial health.
Quality indicators
How to recognize a pure peptide
Purity markers
4White / off-white powder
Typical appearance of sterile lyophilized peptide.
Comes with COA (Certificate of Analysis)
Independent lab analysis, ≥98% purity.
Intact, sealed vial
Rubber stopper + aluminum crimp intact, ensuring sterility.
Dissolves clear
Clear solution after reconstitution, no sediment.
Use caution
1Storage temperature
Extended room-temp exposure may reduce potency.
Do not use
2Discoloration / sediment
Yellow, cloudy or particulate solution, indicates degradation, do not use.
Damaged packaging
Cracked vial or loose cap, sterility compromised, discard.
Interactions & stacks
What to combine and what to avoid
Humanin
SynergisticMitochondrial-derived peptide, neuro & metabolic protection
MOTS-c
SynergisticMitochondrial peptide, metabolism and AMPK activation
NAD+
SynergisticSirtuin activation + epigenetic modulation.
Vitamin C / Zinc / B-complex
SynergisticSupports collagen synthesis and antioxidant capacity.
Caffeine
Requires timingCompatible with morning dosing; avoid late-day stacking.
Rapamycin
Use cautionmTOR-suppression effect may be amplified, consult specialist.
NSAIDs (Ibuprofen, ASA)
Use cautionLong-term concurrent use may blunt regenerative effects.
Alcohol
AvoidReduces recovery and increases side-effect risk.
Safety
Side effects, stop signs, contraindications
Side effects · 3
- Transient irritation at site
- Mild headache
- Mild fatigue in first 1–2 weeks
Contraindications · 5
- Pregnancy and breastfeeding
- Active malignancy
- Known allergy to the peptide or its components
- Severe hepatic or renal impairment (medical consultation required)
- Age under 18
Related Peptides
Same therapeutic category
Studies
Related research and clinical findings
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The information here is strictly for educational and scientific purposes. It does not replace medical advice or clinical consultation, and it does not encourage illegal substance or pharmaceutical use. Data is sourced. When in doubt, consult your doctor.