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PreclinicalResearch compound

Semax

ACTH(4-10) analog, nootropic nasal spray

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Semax vial

Related comparisons

Semax vs NA-Semax-Amidate vs Adamax

WHAT IS SEMAX?

Detailed overview

Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is an ACTH(4-10) analog registered in Russia for ischaemic stroke and cognitive enhancement. Available in two forms: subcutaneous injection (research protocol) and intranasal spray (Russian clinical practice primary route).

Type

ACTH(4-10) analog

Structure

Met-Glu-His-Phe-Pro-Gly-Pro

Status

Registered RU

Storage

2–8°C

Source

Placeholder, image later

Cognitive function

BDNF and NGF rise, supporting synaptic plasticity, LTP and the formation of new neural connections. Attention, working memory and task-switching measurably improve within 2–4 weeks. Neuroprotection: oxidative stress, excitotoxicity and glial inflammation drop, especially in aged, stressed or trauma-exposed brains. Mood stabilization and anxiety reduction follow via HPA-axis modulation. Effects are cumulative.

Data console

Lab data

/lab/molecular-data.jsonLIVE
> ClassificationACTH(4-10) analog
> StructureMet-Glu-His-Phe-Pro-Gly-Pro
> Molecular weightN/A
> Target area-
> Storage2–8°C
> Stability~30 days reconstituted

Research indications

Investigated uses and mechanisms

Memory & learning

Supports hippocampal synaptic plasticity.

Neuroprotection

Slows oxidative stress and neurodegenerative processes.

Focus & mood

BDNF / NGF rise; attention and emotional regulation improve.

Reconstitution

How to prepare, step by step

Important

Sterile technique required. Use bacteriostatic water (BAC) only. Never distilled or tap water.

  1. 01

    5 mg lyophilized vial + 2 ml bacteriostatic water

  2. 02

    Inject water slowly onto vial wall, NOT directly onto powder

  3. 03

    Wait 30 seconds, swirl gently (DO NOT shake)

  4. 04

    Storage: refrigerated (2–8°C), max 28 days

Quality indicators

How to recognize a pure peptide

Purity markers

4

  • White / off-white powder

    Typical appearance of sterile lyophilized peptide.

  • Comes with COA (Certificate of Analysis)

    Independent lab analysis, ≥98% purity.

  • Intact, sealed vial

    Rubber stopper + aluminum crimp intact, ensuring sterility.

  • Dissolves clear

    Clear solution after reconstitution, no sediment.

Use caution

1

  • Storage temperature

    Extended room-temp exposure may reduce potency.

Do not use

2

  • Discoloration / sediment

    Yellow, cloudy or particulate solution, indicates degradation, do not use.

  • Damaged packaging

    Cracked vial or loose cap, sterility compromised, discard.

Interactions & stacks

What to combine and what to avoid

Selank

Synergistic

Tuftsin analog, anxiolytic nootropic

Cerebrolysin

Synergistic

Neuropeptide mixture, neuroprotective / regenerative

Lion's Mane

Synergistic

Complementary NGF / BDNF pathway activation.

Vitamin C / Zinc / B-complex

Synergistic

Supports collagen synthesis and antioxidant capacity.

Modafinil

Requires timing

Combine in the morning; monitor for psychoactive interactions.

Caffeine

Requires timing

Compatible with morning dosing; avoid late-day stacking.

NSAIDs (Ibuprofen, ASA)

Use caution

Long-term concurrent use may blunt regenerative effects.

Alcohol

Avoid

Reduces recovery and increases side-effect risk.

Safety

Side effects, stop signs, contraindications

Side effects · 4

  • Headache, dizziness (during titration)
  • Transient mood shift
  • Sleep disturbance (if dosed late)
  • Mild injection-site irritation

Contraindications · 5

  • Pregnancy and breastfeeding
  • Active malignancy
  • Known allergy to the peptide or its components
  • Severe hepatic or renal impairment (medical consultation required)
  • Age under 18

Related Peptides

Same therapeutic category

Studies

Related research and clinical findings

Research
Bull Exp Biol Med · 2006

Neuroprotective and antiamnesic effects of Semax during experimental ischemic infarction of the cerebral cortex

Romanova GA, Barskov IV, Ostrovskaya RU, et al.

Semax exerts neuroprotective and antiamnesic effects in experimental ischemic cortical infarction via intranasal administration.

PMID: 17603664Open

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MolekulaX Editorial Team·Source-verified · PubMed · FDA · EMA
Updated: June 19, 2026

The information here is strictly for educational and scientific purposes. It does not replace medical advice or clinical consultation, and it does not encourage illegal substance or pharmaceutical use. Data is sourced. When in doubt, consult your doctor.