MENT (Trestolone) – 19‑Nor progestin frame
Trestolone (7α-methyl-19-nortestosterone, MENT) Population Council male contraceptive candidate. 19-Nor framework progestogen emphasis: moderate PR affinity → spermatogenesis suppression + bodybuilding-context prolactin monitoring need. Cross-framed: synthetic androgen frame [[ment-test]] separate entry.
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WHAT IS MENT (TRESTOLONE) – 19-NOR PROGESTIN FRAME?
Detailed overview
MENT (Trestolone, 7α-methyl-19-nortestosterone) can be classified BOTH as a synthetic androgen AND as a 19-nortestosterone derivative – this entry frames it within the 19-Nor (Nandrolone family) framework: removal of the 19-carbon methyl group gives the molecule non-trivial PROGESTOGENIC ACTIVITY (moderate PR-binding affinity, Beri 1998 PMID 9879986), which was the primary mechanism of the Population Council male contraceptive development (1999-2005, Anderson 1999 PMID 10522995): progesterone-mediated negative feedback on the HPG axis → sustained azoospermia/oligospermia in 90%+ of clinical-trial participants. The 7α-methyl substitution inhibits 5α-reductase substrate binding (does NOT convert to DHT) AND increases AR affinity (~8-10x Test, Sundaram 1993 PMID 8489761), but from the 19-Nor framework perspective the PR activity is the salient marker – this explains the elevated prolactin levels documented in clinical trials and the high efficacy of the contraceptive effect. In bodybuilding context PR activity plays a central role in the side-effect profile: prolactin monitoring is mandatory, cabergoline standby is standard. Aromatization weaker than on Test (7α-methylestradiol has lower ER affinity). NOT 17α-alkylated → low hepatotoxicity. Two variants: Acetate (short, ~8h) and Enanthate (slow, ~5-7 days). WADA-banned year-round. Cross-framed entry: the synthetic androgen perspective [[ment-test]] has a separate entry (Test column) – same molecule, different emphasis.
Mechanism
19-nor-T derivative with moderate PR affinity + AR agonist (8-10x T); progestogen-mediated HPG suppression
PR affinity (Cook 1996)
Moderate – quasi-progesterone-receptor agonist, contraceptive significance
Anabolic:Androgenic
~2300:650 (extrapolated in vitro AR-binding)
Half-life
~8 h (Ac), 5-7 d (Enan)
Legal status
Never an Rx (Population Council Phase III stalled). UGL only. WADA-banned.
Data console
Lab data
Safety
Side effects, stop signs, contraindications
Side effects · 7
- Deep HPTA suppression and rapid, profound spermatogenesis inhibition (90%+ azoospermia/oligospermia within 4 weeks in trials) – the progestogenic PR-mediated feedback is stronger than with typical androgens, fertility recovery 6–12 months.
- Elevated prolactin (from PR activity) → lowered libido, erectile dysfunction and prolactin-driven gynecomastia, paradoxically even though aromatization is relatively mild.
- Adverse lipid profile: moderate-to-marked drop in HDL cholesterol, raising cardiovascular risk during the cycle.
- Androgenic effects: acne, increased sebum, and scalp hair thinning in predisposed users (it is NOT an 5α-reductase substrate so scalp-DHT is lower, but the high AR affinity keeps it androgenic).
- Mood and psychiatric disturbances: irritability, anxiety, and depressive episodes in rare case reports (19-nor / progestogen-type effect).
- Injection-site reaction (PIP, pain, swelling) – stronger with the Acetate ester due to higher mg/ml concentration and frequent EOD/daily dosing, milder with the Enanthate.
- Mild estrogen-mediated effects (water retention, rise in blood pressure): CYP19 aromatizes it to 7α-methylestradiol with lower ER affinity than plain estradiol, so E2 side effects are milder but not absent.
Contraindications · 7
- Use by women – the extremely high AR affinity (~8–10x testosterone) causes rapid, partly irreversible virilization (voice deepening, hirsutism, clitoral enlargement).
- Pregnancy and breastfeeding – androgenic/progestogenic activity carries teratogenic risk (fetal virilization); absolute contraindication.
- Pre-existing hyperprolactinemia or prolactinoma – the prolactin rise from PR activity can worsen the condition; absolute contraindication.
- Active or prior hormone-sensitive cancer (prostate, breast carcinoma) – androgenic stimulation may promote progression.
- Established cardiovascular disease, uncontrolled hypertension or adverse lipid profile – the HDL drop and water retention further worsen the risk.
- Psychiatric predisposition (depression, anxiety disorder) – the 19-nor/progestogen-type mood effects may trigger or worsen symptoms.
- Planned near-term fatherhood or need to preserve fertility – recovery after the deep spermatogenesis suppression takes 6–12 months and PCT alone does not sufficiently accelerate it.
Related Performance Compounds
Same therapeutic category
Studies
Related research and clinical findings
7 alpha-methyl-19-nortestosterone (MENT): the optimal androgen for male contraception
Sundaram K, Kumar N, Bardin CW.
7α-methyl-19-nortestosterone maintains sexual behavior and mood in hypogonadal men
Anderson RA, Wallace AM, Sattar N, Kumar N, Sundaram K.
Pharmacokinetics and pharmacodynamics of 7alpha-methyl-19-nortestosterone after intramuscular administration in healthy men
Suvisaari J, Sundaram K, Noé G et al.
Estrogenic and progestational activity of 7alpha-methyl-19-nortestosterone, a synthetic androgen
Beri R, Kumar N, Savage T et al.
Adverse health consequences of performance-enhancing drugs: an Endocrine Society scientific statement
Pope HG Jr, Wood RI, Rogol A, Nyberg F, Bowers L, Bhasin S.
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The information here is for educational and scientific purposes only. Performance-enhancing compounds (AAS, prohormones, stimulants, doping agents) are illegal without prescription in Hungary and most of the EU, and carry serious health and legal risks. WADA bans them in competitive sport. This is NOT a usage guide, and we do not encourage any illegal use. If you do use them, medical supervision and regular bloodwork are ESSENTIAL. Severe endocrine, cardiovascular, hepatic and psychiatric side effects are possible.