Why are RAD-140 studies cited on a RAD-150 page?

Because no published study exists on RAD-150, and saying so is more honest than concealing it. RAD-150 is the benzoate ester of RAD-140, that is, a prodrug: it is cleaved in the body and the actual active agent is RAD-140. Data on RAD-140 are therefore relevant but not the same as if RAD-150 had been studied. What may differ: rate of absorption, peak concentration and duration. Nobody has measured that in humans. Elsewhere these papers are often cited as though they were RAD-150 evidence; here we deliberately mark where they come from.

Can it really cause heart problems?

Several independent medical case reports are linked to RAD-140, and they do not describe mild complaints. Padappayil 2022 described acute myocarditis, Schwartzman 2024 myopericarditis, and Skorupski 2024 catastrophic heart failure. What deserves particular attention: these arose in young, previously healthy people. A case report alone does not prove causation and gives no frequency, but serious events of a similar pattern from several independent sources are a signal that should not be brushed aside. For chest pain, breathlessness or palpitations the correct response is to stop immediately and seek medical assessment.

EmergingResearch compound

RAD‑150 (TLB‑150)

Name: RAD-150 (TLB-150)
Creator: MolekulaX

The benzoate ester of RAD-140. Not a single study exists on RAD-150 itself; all the evidence below concerns RAD-140 and describes myocarditis and heart failure.

Available at

DEUSPOWERProduct page

RAD-150 (capsules)

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WHAT IS RAD-150 (TLB-150)?

Detailed overview

RAD-150 (TLB-150 benzoate) is not an independent compound in the pharmacological sense but the benzoate ester of RAD-140 (testolone). The ester is cleaved in the body and the real active agent is RAD-140. Shops market it as a longer-acting, more stable version. From this follows the most important sentence on this page: not a single published study exists on RAD-150 itself. Every paper cited below concerns RAD-140, and we say so deliberately, because elsewhere they are often sold as RAD-150 evidence. What is known about RAD-140 may apply to RAD-150 since it converts to the same molecule, but absorption, peak concentration and time course may differ, and nobody has measured that. The available human data on RAD-140 are not reassuring, and they are not efficacy data but harm case reports. Padappayil 2022 described acute myocarditis, the Schwartzman 2024 JACC case report myopericarditis, and Skorupski 2024 catastrophic heart failure linked to SARM abuse. These arose in young, otherwise healthy people. In animals the picture also contradicts the marketing: in Brown 2023, RAD-140 impaired skeletal muscle adaptation to exercise in female mice, worsened frailty status and raised mortality risk. That is precisely the opposite of what it is used for.

What it actually is

The benzoate ester of RAD-140 (testolone); cleaved to RAD-140 in the body.

Evidence of its own

None. No published study exists on RAD-150 itself.

Human data on RAD-140

Case reports of myocarditis, myopericarditis and heart failure in young users.

Animal finding

Brown 2023: impaired muscle adaptation and raised mortality risk in mice.

Legal status

Not a medicine. WADA-banned year-round (S1.2).

Data console

Lab data

/lab/molecular-data.jsonLIVE
> Androgenic:AnabolicRAD-140 has been described as muscle-selective relative to the prostate, but no reliable ratio based on human data is available, and for RAD-150 there are no data at all.
> AR bindingRAD-140 is a high-affinity non-steroidal androgen receptor …
> Active half-lifeismeretlen; a RAD-140 felezési ideje ~60 h
> Detection windowDoping laboratories screen for SARMs including RAD-140 and its metabolites by liquid chromatography-tandem mass spectrometry. To be avoided by tested athletes.
> AromatizationNO. RAD-140 and its ester are non-steroidal, are not substrates for aromatase and do not convert to estradiol.
> HepatotoxicityHIGH RISK. SARM-associated drug-induced liver injury is well documented within the class and applies to RAD-140. If used, regular liver enzyme monitoring is essential, but it bears emphasis that the most serious reported events with RAD-140 involved the heart rather than the liver.

Safety

Side effects, stop signs, contraindications

Side effects · 4

Myocarditis and heart failure: several independent case reports describe acute myocarditis, myopericarditis and even catastrophic heart failure in young, otherwise healthy RAD-140 users.
Liver injury: SARM-associated drug-induced liver injury is well documented within the class and applies to RAD-140 as well.
HPTA suppression and lipid deterioration: endogenous testosterone production falls and HDL cholesterol declines.
An animal warning: in Brown 2023 RAD-140 IMPAIRED skeletal muscle adaptation in female mice, worsened frailty status and raised mortality risk. That is the opposite of what the compound is expected to do.

Contraindications · 4

Any known cardiac disease: the myocarditis and heart failure case reports linked to RAD-140 arose in young healthy people, which implies a worse outcome on an already diseased heart.
Existing liver disease or elevated baseline ALT/AST.
Pregnancy and breastfeeding: androgen receptor activation can cause fetal virilization, use is prohibited.
Competitive sport under testing: WADA bans SARMs year-round (S1.2) and screens for them routinely.

Related Performance Compounds

Same therapeutic category

Studies

Related research and clinical findings

Clinical and experimental pharmacology & physiology

RAD140 (Testolone) negatively impacts skeletal muscle adaptation, frailty status and mortality risk in female mice.

Brown AM, Ganjayi MS, Baumann CW

PMID: 37758180Open

Cureus

Acute Myocarditis From the Use of Selective Androgen Receptor Modulator (SARM) RAD-140 (Testolone).

Padappayil RP, Chandini Arjun A, Vivar Acosta J

PMID: 35233331Open

JACC. Case reports

Myopericarditis Following Use of Selective Androgen Receptor Modifier "RAD-140".

Schwartzman KH, Kohli U, Chaudhuri NR

PMID: 39157568Open

Polish archives of internal medicine

Selective androgen receptor modulator abuse-induced heart failure: catastrophic effects of RAD-140 (Testolone).

Skorupski WJ, Marko A, Janus M

PMID: 38864168Open

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MolekulaX Editorial Team·Source-verified · PubMed · FDA · EMA

The information here is for educational and scientific purposes only. Performance-enhancing compounds (AAS, prohormones, stimulants, doping agents) are illegal without prescription in Hungary and most of the EU, and carry serious health and legal risks. WADA bans them in competitive sport. This is NOT a usage guide, and we do not encourage any illegal use. If you do use them, medical supervision and regular bloodwork are ESSENTIAL. Severe endocrine, cardiovascular, hepatic and psychiatric side effects are possible.