Afinil family (eugeroics)
Modafinil vs Armodafinil vs Flmodafinil
The table compares the compounds’ key data from their entry pages. Open each compound’s full entry for details. Educational content, not medical advice.
| Modafinil | Armodafinil | Flmodafinil | |
|---|---|---|---|
| What it is | FDA-approved wakefulness-promoting agent (Provigil). Selective DAT inhibitor, Rx for narcolepsy, sleep apnea, shift-work disorder. | R-enantiomer of Modafinil, longer half-life, smoother focus. | Bisfluoromodafinil (CRL-40,940), roughly 3× more potent in vivo. |
| Mechanism | Selective DAT inhibitor | DAT inhibition + orexin/histamine | Modafinil-like, DAT inhibition |
| Half-life | 12-15 hours | ~15 h | Limited human data |
| Onset | 30-60 min | — | — |
| Legal status | FDA Rx (Provigil) | FDA Schedule IV (Nuvigil) | Investigational, not approved |
| FDA boxed warning | Severe skin reactions (SJS/TEN/DRESS) | — | — |
| Full entry | Open → | Open → | Open → |
What it is
ModafinilFDA-approved wakefulness-promoting agent (Provigil). Selective DAT inhibitor, Rx for narcolepsy, sleep apnea, shift-work disorder.
ArmodafinilR-enantiomer of Modafinil, longer half-life, smoother focus.
FlmodafinilBisfluoromodafinil (CRL-40,940), roughly 3× more potent in vivo.
Mechanism
ModafinilSelective DAT inhibitor
ArmodafinilDAT inhibition + orexin/histamine
FlmodafinilModafinil-like, DAT inhibition
Half-life
Modafinil12-15 hours
Armodafinil~15 h
FlmodafinilLimited human data
Onset
Modafinil30-60 min
Armodafinil—
Flmodafinil—
Legal status
ModafinilFDA Rx (Provigil)
ArmodafinilFDA Schedule IV (Nuvigil)
FlmodafinilInvestigational, not approved
FDA boxed warning
ModafinilSevere skin reactions (SJS/TEN/DRESS)
Armodafinil—
Flmodafinil—