Afinil family (eugeroics)EugeroicA class of wakefulness-promoting compounds (e.g. the modafinil type) acting differently from classic stimulants.
Modafinil vs Armodafinil vs Flmodafinil
The table compares the compounds’ key data from their entry pages. Open each compound’s full entry for details. Educational content, not medical advice.
| MModafinil | AArmodafinil | FFlmodafinil | |
|---|---|---|---|
| What it is | FDA-approved wakefulness-promoting agent (Provigil). Selective DAT inhibitor, Rx for narcolepsy, sleep apnea, shift-work disorder. | R-enantiomer of Modafinil, longer half-life, smoother focus. | Bisfluoromodafinil (CRL-40,940), roughly 3× more potent in vivo. |
| MechanismMechanism of actionThe molecular pathway by which a compound acts in the body (e.g. which receptor or enzyme it binds). | Selective DAT inhibitor | DAT inhibition + orexin/histamine | Modafinil-like, DAT inhibition |
| Half-lifeHalf-lifeThe time for the compound’s plasma concentration to fall by half; indicates how fast it clears and how often it is dosed. | 12-15 hours | ~15 h | Limited human data |
| OnsetOnsetThe time from dosing until a measurable effect appears. | 30-60 min | — | — |
| Legal statusLegal / WADA statusThe compound’s regulatory status (e.g. prescription) and its place on the WADA prohibited-in-sport list. | FDA Rx (Provigil) | FDA Schedule IV (Nuvigil) | Investigational, not approved |
| FDA boxed warning | Severe skin reactions (SJS/TEN/DRESS) | — | — |
| Full entry | Open → | Open → | Open → |
What it is
ModafinilFDA-approved wakefulness-promoting agent (Provigil). Selective DAT inhibitor, Rx for narcolepsy, sleep apnea, shift-work disorder.
ArmodafinilR-enantiomer of Modafinil, longer half-life, smoother focus.
FlmodafinilBisfluoromodafinil (CRL-40,940), roughly 3× more potent in vivo.
MechanismMechanism of actionThe molecular pathway by which a compound acts in the body (e.g. which receptor or enzyme it binds).
ModafinilSelective DAT inhibitor
ArmodafinilDAT inhibition + orexin/histamine
FlmodafinilModafinil-like, DAT inhibition
Half-lifeHalf-lifeThe time for the compound’s plasma concentration to fall by half; indicates how fast it clears and how often it is dosed.
Modafinil12-15 hours
Armodafinil~15 h
FlmodafinilLimited human data
OnsetOnsetThe time from dosing until a measurable effect appears.
Modafinil30-60 min
Armodafinil—
Flmodafinil—
Legal statusLegal / WADA statusThe compound’s regulatory status (e.g. prescription) and its place on the WADA prohibited-in-sport list.
ModafinilFDA Rx (Provigil)
ArmodafinilFDA Schedule IV (Nuvigil)
FlmodafinilInvestigational, not approved
FDA boxed warning
ModafinilSevere skin reactions (SJS/TEN/DRESS)
Armodafinil—
Flmodafinil—