Flmodafinil
Bisfluoromodafinil (CRL-40,940), roughly 3× more potent in vivo.
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WHAT IS FLMODAFINIL?
Detailed overview
Flmodafinil (CRL-40,940, lauflumide) is a bis-(p-fluoro) phenyl substituted racemic derivative of Modafinil. Animal models describe ~3× higher in vivo potency; its aqueous solubility and bioavailability are better than Modafinil`s. In clinical trials it is **better tolerated than Modafinil with fewer adrenergic-like side effects** and **less negative impact on sleep architecture** (PMC 6104159). Mechanism: atypical DAT inhibition (Methylphenidate-like profile) complemented by orexin/histamine modulation. Fewer CYP-enzyme interactions than Modafinil (PMID 38852786) → fewer drug-drug interactions. Human Phase 1 studies have been conducted but it is not an approved medicine. Banned in the UK under the Psychoactive Substances Act.
Mechanism
Modafinil-like, DAT inhibition
Half-life
Limited human data
Legal status
Investigational, not approved
Safety
Side effects, stop signs, contraindications
Side effects · 7
- Headache, the most common modafinil-class side effect
- Insomnia, disrupted sleep, especially with late dosing (though milder than with Modafinil)
- Anxiety, nervousness, restlessness
- Appetite loss, nausea, mild GI discomfort
- Dry mouth, dizziness
- Mildly elevated heart rate or blood pressure (fewer adrenergic effects than Modafinil)
- Rare but serious skin reaction risk in this class (rash, Stevens-Johnson syndrome)
Contraindications · 6
- Pregnancy and breastfeeding: safety not established, avoid
- Cardiovascular disease, arrhythmia, uncontrolled hypertension: caution due to dopaminergic/stimulant profile
- History of anxiety disorders: may worsen anxiety and restlessness
- Hormonal contraception: the modafinil class may reduce its efficacy (backup method advised)
- Prior serious skin reaction (rash, hypersensitivity) to modafinil-type agents: contraindicated
- Experimental, unapproved compound with limited human data; extra caution with hepatic or renal impairment
Related Nootropics
Same therapeutic category
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The information here is strictly for educational and scientific purposes. It does not replace medical advice or clinical consultation, and it does not encourage illegal substance or pharmaceutical use. Data is sourced. When in doubt, consult your doctor.